P-165: Comparison of Urinary and Recombinant Human Chorionic Gonadotropin during Ovulation Induction in Intrauterine Insemination Cycles

Background: Urinary human chorionic gonadotropin is the most widely used medicine for ovulation in ovarian stimulation cycles. Recently however, recombinant HCG has also become commercially available. This study presents compare the use of recombinant hCG with urinary hCG during controlled ovarian hyperstimulation and intra uterine insemination (COH-IUI ) cycles Materials and Methods: This is study is a randomlycontrolled clinical trial that includes women aged between 20 and 44 years who were admitted to the infertility ward of Zanan Hospital, Tehran. The subjects were undergoing COH-IUI during the period of years 2010 to 2011. Ovulation induction was started on patients who had criteria for COH-IUI ,when there was at least one dominant follicle (≥ 15), single IUI was performed after 36 hours of hCG injection (either recombinant or urinary). Rate of ovulation and pregnancy were compared in two groups. Results: In 537 cycles of COH-IUI that were analyzed, pregnancy occurred in 147 cases (27%). In urinary hCG group, 92 out of 333 cases became pregnant (27%) while in the recombinant hCG group 56 out of 204 cases became pregnant (27.5%) Conclusion: Findings of this study indicate that the pregnancy and ovulation rate in two groups are not different.